diff --git a/conn.go b/conn.go
index 72154325..5819611a 100644
--- a/conn.go
+++ b/conn.go
@@ -740,7 +740,7 @@ optionLoop:
 	rows := c.getRows(ctx, sql, args)
 
 	var err error
-	sd := c.preparedStatements[sql]
+	sd, explicitPreparedStatement := c.preparedStatements[sql]
 	if sd != nil || mode == QueryExecModeCacheStatement || mode == QueryExecModeCacheDescribe || mode == QueryExecModeDescribeExec {
 		if sd == nil {
 			switch mode {
@@ -806,7 +806,7 @@ optionLoop:
 			resultFormats = c.eqb.resultFormats
 		}
 
-		if mode == QueryExecModeCacheDescribe {
+		if !explicitPreparedStatement && mode == QueryExecModeCacheDescribe {
 			rows.resultReader = c.pgConn.ExecParams(ctx, sql, c.eqb.paramValues, sd.ParamOIDs, c.eqb.paramFormats, resultFormats)
 		} else {
 			rows.resultReader = c.pgConn.ExecPrepared(ctx, sd.Name, c.eqb.paramValues, c.eqb.paramFormats, resultFormats)
diff --git a/conn_test.go b/conn_test.go
index 675fba17..5115d76e 100644
--- a/conn_test.go
+++ b/conn_test.go
@@ -472,6 +472,20 @@ func TestPrepareIdempotency(t *testing.T) {
 	}
 }
 
+func TestPrepareStatementCacheModes(t *testing.T) {
+	t.Parallel()
+
+	pgxtest.RunWithQueryExecModes(context.Background(), t, defaultConnTestRunner, nil, func(ctx context.Context, t testing.TB, conn *pgx.Conn) {
+		_, err := conn.Prepare(context.Background(), "test", "select $1::text")
+		require.NoError(t, err)
+
+		var s string
+		err = conn.QueryRow(context.Background(), "test", "hello").Scan(&s)
+		require.NoError(t, err)
+		require.Equal(t, "hello", s)
+	})
+}
+
 func TestListenNotify(t *testing.T) {
 	t.Parallel()