diff --git a/pgconn/pgconn.go b/pgconn/pgconn.go
index 7426add9..bb4d35a9 100644
--- a/pgconn/pgconn.go
+++ b/pgconn/pgconn.go
@@ -1871,6 +1871,11 @@ func (p *Pipeline) getResultsPrepare() (*StatementDescription, error) {
 			copy(psd.Fields, msg.Fields)
 			return psd, nil
 
+		// NoData is returned instead of RowDescription when there is no expected result. e.g. An INSERT without a RETURNING
+		// clause.
+		case *pgproto3.NoData:
+			return psd, nil
+
 		// These should never happen here. But don't take chances that could lead to a deadlock.
 		case *pgproto3.ErrorResponse:
 			pgErr := ErrorResponseToPgError(msg)
diff --git a/pgconn/pgconn_test.go b/pgconn/pgconn_test.go
index 0fba9417..598d6629 100644
--- a/pgconn/pgconn_test.go
+++ b/pgconn/pgconn_test.go
@@ -2102,10 +2102,15 @@ func TestPipelinePrepare(t *testing.T) {
 	require.NoError(t, err)
 	defer closeConn(t, pgConn)
 
+	result := pgConn.ExecParams(context.Background(), `create temporary table t (id text primary key)`, nil, nil, nil, nil).Read()
+	require.NoError(t, result.Err)
+
 	pipeline := pgConn.StartPipeline(context.Background())
 	pipeline.SendPrepare("selectInt", "select $1::bigint as a", nil)
 	pipeline.SendPrepare("selectText", "select $1::text as b", nil)
 	pipeline.SendPrepare("selectNoParams", "select 42 as c", nil)
+	pipeline.SendPrepare("insertNoResults", "insert into t (id) values ($1)", nil)
+	pipeline.SendPrepare("insertNoParamsOrResults", "insert into t (id) values ('foo')", nil)
 	err = pipeline.Sync()
 	require.NoError(t, err)
 
@@ -2133,6 +2138,20 @@ func TestPipelinePrepare(t *testing.T) {
 	require.Equal(t, string(sd.Fields[0].Name), "c")
 	require.Equal(t, []uint32{}, sd.ParamOIDs)
 
+	results, err = pipeline.GetResults()
+	require.NoError(t, err)
+	sd, ok = results.(*pgconn.StatementDescription)
+	require.Truef(t, ok, "expected StatementDescription, got: %#v", results)
+	require.Len(t, sd.Fields, 0)
+	require.Equal(t, []uint32{pgtype.TextOID}, sd.ParamOIDs)
+
+	results, err = pipeline.GetResults()
+	require.NoError(t, err)
+	sd, ok = results.(*pgconn.StatementDescription)
+	require.Truef(t, ok, "expected StatementDescription, got: %#v", results)
+	require.Len(t, sd.Fields, 0)
+	require.Len(t, sd.ParamOIDs, 0)
+
 	results, err = pipeline.GetResults()
 	require.NoError(t, err)
 	_, ok = results.(*pgconn.PipelineSync)